Phys.org
Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While the high-resolution structures of EP2, EP3 and EP4 have been resolved, EP1 remained structurally uncharacterized due to its intrinsic instability…
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Scientists map activation of prostaglandin E₂ receptor EP1 at atomic level
Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While the high-resolution structures of EP2, EP3 and EP4 have been resolved, EP1 remained structurally uncharacterized due to its intrinsic instability…