National Academy of Sciences
Proceedings of the National Academy of Sciences, Volume 122, Issue 5, February 2025.
SignificanceEffective delivery strategies are vital for message RNA (mRNA) vaccines and therapeutics, with lipid nanoparticles (LNPs) being forefront. Developing ionizable lipids, a key LNP component, traditionally involves complex, multistep synthesis …
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Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
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Proceedings of the National Academy of Sciences, Volume 122, Issue 5, February 2025. SignificanceEffective delivery strategies are vital for message RNA (mRNA) vaccines and therapeutics, with lipid nanoparticles (LNPs) being forefront. Developing ionizable lipids, a key LNP component, traditionally involves complex, multistep synthesis …
