Nature.com
Nature Biotechnology, Published online: 03 December 2024; doi:10.1038/s41587-024-02495-7Proteolytic chimeras constructed from various bioactive modules can degrade either cytoplasmic or extracellular proteins, but their pharmacology faces challenges. Now, a protein degradation platform built with engineered platelets enables the targeted depletion of intracellular and extracellular proteins at hemorrhagic sites…
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Proteolytic platelets as targeted protein degraders
Becki Klemp
20:19
Nature Biotechnology, Published online: 03 December 2024; doi:10.1038/s41587-024-02495-7Proteolytic chimeras constructed from various bioactive modules can degrade either cytoplasmic or extracellular proteins, but their pharmacology faces challenges. Now, a protein degradation platform built with engineered platelets enables the targeted depletion of intracellular and extracellular proteins at hemorrhagic sites…
