Nature.com
Nature Biotechnology, Published online: 23 September 2025; doi:10.1038/s41587-025-02861-zMost bacteria cannot be grown in the laboratory, which means that their genetic diversity is hidden to traditional culture-based studies. We combined a new DNA extraction method, long-read sequencing, bioinformatics and chemical synthesis to access the genetic diversity of uncultured soil bacteria and abiotically decode it to discover bioactive small molecules…
Read More
Long-read sequencing and chemical synthesis access previously hidden antibiotics
Yuri Schewe
02:20
Nature Biotechnology, Published online: 23 September 2025; doi:10.1038/s41587-025-02861-zMost bacteria cannot be grown in the laboratory, which means that their genetic diversity is hidden to traditional culture-based studies. We combined a new DNA extraction method, long-read sequencing, bioinformatics and chemical synthesis to access the genetic diversity of uncultured soil bacteria and abiotically decode it to discover
