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Nature Biotechnology, Published online: 03 March 2025; doi:10.1038/s41587-025-02600-4DNA delivery using lipid nanoparticles results in severe toxicity in mice. However, we find that the incorporation of endogenous anti-inflammatory lipids into the lipid nanoparticles mitigates this toxicity and enables prolonged gene expression…
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Improving the safety of lipid nanoparticle-based DNA delivery for extended gene expression
Elida Ramage
10:22
Nature Biotechnology, Published online: 03 March 2025; doi:10.1038/s41587-025-02600-4DNA delivery using lipid nanoparticles results in severe toxicity in mice. However, we find that the incorporation of endogenous anti-inflammatory lipids into the lipid nanoparticles mitigates this toxicity and enables prolonged gene expression…
