National Academy of Sciences
Proceedings of the National Academy of Sciences, Volume 122, Issue 2, January 2025.
SignificanceEpistatic interactions between mutations are thought to constrain evolution since they make an adaptive landscape in sequence space very rugged. However, an increasing variety of empirical fitness landscapes appear to be both strongly rugged …
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Epistatic hotspots organize antibody fitness landscape and boost evolvability
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Proceedings of the National Academy of Sciences, Volume 122, Issue 2, January 2025. SignificanceEpistatic interactions between mutations are thought to constrain evolution since they make an adaptive landscape in sequence space very rugged. However, an increasing variety of empirical fitness landscapes appear to be both strongly rugged …
