National Academy of Sciences
Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceFerroptosis is an iron-dependent cell death mechanism that results from increased oxidation of cell membrane lipids. We conducted a CRISPR-based positive selection screen in clear cell ovarian cancer cells treated with a nanoparticle drug to …
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CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis
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Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025. SignificanceFerroptosis is an iron-dependent cell death mechanism that results from increased oxidation of cell membrane lipids. We conducted a CRISPR-based positive selection screen in clear cell ovarian cancer cells treated with a nanoparticle drug to …
