Nature.com
Nature Biotechnology, Published online: 19 February 2025; doi:10.1038/s41587-025-02580-5The mechanism of translation initiation in linear and circular mRNAs influences translation efficiency. Covalent attachment of an N7-methylguanosine (m7G) cap increases protein production from circular mRNAs in mice. Hybridization with capped endogenous RNAs also promotes protein production in cells…
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Covalently or non-covalently attached m7G cap enhances protein production from circular mRNA
Lawanda Volkman
09:20
Nature Biotechnology, Published online: 19 February 2025; doi:10.1038/s41587-025-02580-5The mechanism of translation initiation in linear and circular mRNAs influences translation efficiency. Covalent attachment of an N7-methylguanosine (m7G) cap increases protein production from circular mRNAs in mice. Hybridization with capped endogenous RNAs also promotes protein production in cells…