National Academy of Sciences
Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025.
SignificanceWe identify the cell type–specific selection of T cells with a synonymous mitochondrial DNA variant inMT-CO1,reminiscent of the purifying selection of pathogenic alleles. Mechanistically, we implicate the limited mitochondrial tRNA pool to …
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Cell type–specific purifying selection of synonymous mitochondrial DNA variation
05:20
Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025. SignificanceWe identify the cell type–specific selection of T cells with a synonymous mitochondrial DNA variant inMT-CO1,reminiscent of the purifying selection of pathogenic alleles. Mechanistically, we implicate the limited mitochondrial tRNA pool to …
