National Academy of Sciences
Proceedings of the National Academy of Sciences, Volume 122, Issue 20, May 2025.
SignificanceTerminal sialylation of the single IgG Fc glycan bestows anti-inflammatory activity to subclasses IgG1 and IgG3 but not IgG2 nor IgG4. The anti-inflammatory activity of sialylated IgG1 and IgG3 was dependent on type II Fc γ receptors in vivo…
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Molecular determinants of sialylated IgG anti-inflammatory activity
18:20
Proceedings of the National Academy of Sciences, Volume 122, Issue 20, May 2025. SignificanceTerminal sialylation of the single IgG Fc glycan bestows anti-inflammatory activity to subclasses IgG1 and IgG3 but not IgG2 nor IgG4. The anti-inflammatory activity of sialylated IgG1 and IgG3 was dependent on type II Fc γ receptors in vivo…
